![]() ![]() Annotated Pharmacogenomic Information for LEP.Kyoto Encyclopedia of Genes and Genomes.GenScript latest version of gene cDNA ORF Clone. ![]() BioGRID CRISPR Screen Phenotypes (14 hits/1148 screens).BioGRID Open Repository of CRISPR Screens (ORCS).See identical proteins and their annotated locations for XP_005250397.1 UniProtKB/Swiss-Prot P41159 Conserved Domains (1) summary pfam02024 NC_000007.14 Reference GRCh38.p14 Primary Assembly Range 128241278.128257629 Download GenBank, FASTA, Sequence Viewer (Graphics) Reference GRCh38.p14 Primary Assembly Genomic Model RNAs and proteins are also reported here. RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternateĪssemblies. Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as The following sections contain reference sequences that belong to a See citations in PubMed for homologs of this gene provided by HomoloGene Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2022 Dec. A Case-Control Study of the Association of Leptin Gene Polymorphisms with Plasma Leptin Levels and Obesity in the Kerala Population.Relationship between leptin gene variants (-2548G>A and 19A>G) and obesity among north Indian Punjabi population.Sex-Specific Effects of the Genetic Variant rs10487505 Upstream of leptin in the Development of Obesity.The association between living altitude and serum leptin concentrations in native women.Expression Restricted expression toward fat (RPKM 214.1) See more Orthologs mouse all NEW Try the new Gene table A mutation in this gene has also been linked to type 2 diabetes mellitus development. Mutations in this gene and its regulatory regions cause severe obesity and morbid obesity with hypogonadism in human patients. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis, reproduction, bone formation and wound healing. Circulating leptin binds to the leptin receptor in the brain, which activates downstream signaling pathways that inhibit feeding and promote energy expenditure. Full Name leptin provided by HGNC Primary source HGNC:HGNC:6553 See related Ensembl:ENSG00000174697 MIM:164160 AllianceGenome:HGNC:6553 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo Also known as OB OBS LEPD Summary This gene encodes a protein that is secreted by white adipocytes into the circulation and plays a major role in the regulation of energy homeostasis. ![]()
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